The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis

Pathogenesis of obliterative bronchiolitis in rat heterotopic tracheal allografts An experimental approach to chronic lung allograft rejection

Orthotopic and heterotopic tracheal transplantation model in studying obliterative bronchiolitis.

BACKGROUND Several animal models have been established to investigate the mechanisms of obliterative bronchiolitis after lung transplantation. In this study, we compared three prevalent murine models of obliterative bronchiolitis in terms of several basic pathologic changes in a relatively short span of time after transplantation. METHODS Each of the recipient mice simultaneously received ort...

Revascularization of the graft in obliterative bronchiolitis after heterotopic tracheal transplantation.

Obliterative bronchiolitis is the principal long-term problem for lung transplant patients. One of the simplest and most reproducible animal models of obliterative bronchiolitis is heterotopic tracheal transplantation in subcutaneous tissue, where the graft is not primarily vascularized. We demonstrate here the rapid graft revascularization and the kinetics of expression of its angiogenic and l...

TIMP-1 Deficiency Abrogates Obliterative Airway Disease after Heterotopic Tracheal Transplantation

Obliterative bronchiolitis (OB) is a major cause of allograft dysfunction after lung transplantation and is thought to result from immunologically mediated airway epithelial destruction and luminal fibrosis. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been implicated in the regulation of lung inflammation, airway epithelial repair and extracellular ...

Tissue inhibitor of metalloproteinase-1 deficiency abrogates obliterative airway disease after heterotopic tracheal transplantation.

Obliterative bronchiolitis (OB) is a major cause of allograft dysfunction after lung transplantation and is thought to result from immunologically mediated airway epithelial destruction and luminal fibrosis. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been implicated in the regulation of lung inflammation, airway epithelial repair, and extracellular...